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  Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster.

Moussian, B., Söding, J., Schwarz, H., & Nüsslein-Volhard, C. (2005). Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Developmental Dynamics, 233(3), 1056-1063. doi:10.1002/dvdy.20389.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-EAFD-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C5A0-7
Genre: Journal Article

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1944248.pdf (Publisher version), 603KB
 
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 Creators:
Moussian, B.1, Author
Söding, J.2, Author              
Schwarz, H.1, Author
Nüsslein-Volhard, C.1, Author
Affiliations:
1external, ou_persistent22              
2Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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Free keywords: cuticle; chitin; Drosophila; retroactive; neurotoxin-like proteins
 Abstract: Mutations in the rtv gene cause disarrangement of chitin fibers in the cuticle of the Drosophila larva, and occasionally the cuticle detaches from the epidermis. We have identified the rtv gene, and using the new HHpred homology detection method, we show that the Rtv protein defines a new family of disulfide-rich proteins in insects that are related to vertebrate snake neurotoxin-like proteins, including CD59 and transforming growth factor-β type II receptors. Rtv is an extracellular membrane-anchored protein exposing six aromatic residues that may mediate binding to chitin. We propose that this binding function of Rtv may assist the organization of chitin fibers at the epidermal cell surface during cuticle assembly.

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Language(s): eng - English
 Dates: 2005-04-202005
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/dvdy.20389
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Title: Developmental Dynamics
Source Genre: Journal
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Publ. Info: New York, NY : John Wiley & Sons
Pages: - Volume / Issue: 233 (3) Sequence Number: - Start / End Page: 1056 - 1063 Identifier: ISSN: 1058-8388
CoNE: https://pure.mpg.de/cone/journals/resource/954927516528