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  AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels.

Coles, M., Djuranovic, S., Söding, J., Frickey, T., Koretke, K., Truffault, V., et al. (2005). AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels. Structure, 13(6), 919-928. doi:10.1016/j.str.2005.03.017.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-EBDE-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-09A3-9
Genre: Journal Article

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 Creators:
Coles, M.1, Author
Djuranovic, S.1, Author
Söding, J.2, Author              
Frickey, T.1, Author
Koretke, K.1, Author
Truffault, V.1, Author
Martin, J.1, Author
Lupas, A. N.1, Author
Affiliations:
1external, ou_persistent22              
2Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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 Abstract: AbrB is a key transition-state regulator of Bacillus subtilis. Based on the conservation of a βαβ structural unit, we proposed a β barrel fold for its DNA binding domain, similar to, but topologically distinct from, double-psi β barrels. However, the NMR structure revealed a novel fold, the “looped-hinge helix.” To understand this discrepancy, we undertook a bioinformatics study of AbrB and its homologs; these form a large superfamily, which includes SpoVT, PrlF, MraZ, addiction module antidotes (PemI, MazE), plasmid maintenance proteins (VagC, VapB), and archaeal PhoU homologs. MazE and MraZ form swapped-hairpin β barrels. We therefore reexamined the fold of AbrB by NMR spectroscopy and found that it also forms a swapped-hairpin barrel. The conservation of the core βαβ element supports a common evolutionary origin for swapped-hairpin and double-psi barrels, which we group into a higher-order class, the cradle-loop barrels, based on the peculiar shape of their ligand binding site.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.str.2005.03.017
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Title: Structure
Source Genre: Journal
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Publ. Info: London : Cell Press
Pages: - Volume / Issue: 13 (6) Sequence Number: - Start / End Page: 919 - 928 Identifier: ISSN: 0969-2126
CoNE: https://pure.mpg.de/cone/journals/resource/954927002244_1