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  Intraflagellar transport complex structure and cargo interactions

Bhogaraju, S., Engel, B. D., & Lorentzen, E. (2013). Intraflagellar transport complex structure and cargo interactions. Cilia, 2: 10. doi:10.1186/2046-2530-2-10.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-961B-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-961E-E
Genre: Journal Article

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2046-2530-2-10.pdf (Any fulltext), 755KB
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 Creators:
Bhogaraju, Sagar1, Author              
Engel, Benjamin D, Author
Lorentzen, Esben1, Author              
Affiliations:
1Lorentzen, Esben / Intraflagellar Transport, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565157              

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Free keywords: Intraflagellar transport, Cilium, IFT, IFT complex, IFT cargo
 Abstract: Intraflagellar transport (IFT) is required for the assembly and maintenance of cilia, as well as the proper function of ciliary motility and signaling. IFT is powered by molecular motors that move along the axonemal microtubules, carrying large complexes of IFT proteins that travel together as so-called trains. IFT complexes likely function as adaptors that mediate interactions between anterograde/retrograde motors and ciliary cargoes, facilitating cargo transport between the base and tip of the cilium. Here, we provide an up-to-date review of IFT complex structure and architecture, and discuss how interactions with cargoes and motors may be achieved.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/2046-2530-2-10
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Title: Cilia
Source Genre: Journal
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Publ. Info: London : BioMed Central
Pages: - Volume / Issue: 2 Sequence Number: 10 Start / End Page: - Identifier: ISSN: 2046-2530