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  Neural control of vascular reactions: Impact of emotion and attention

Okon-Singer, H., Mehnert, J., Hoyer, J., Hellrung, L., Schaare, H. L., Dukart, J., et al. (2014). Neural control of vascular reactions: Impact of emotion and attention. The Journal of Neuroscience, 34(12), 4251-4259. doi:10.1523/JNEUROSCI.0747-13.2014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-0F04-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7EE3-0
Genre: Journal Article

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 Creators:
Okon-Singer, Hadas1, 2, 3, Author              
Mehnert, Jan2, 4, 5, Author              
Hoyer, Jana2, Author              
Hellrung, Lydia2, Author              
Schaare, Herma Lina2, Author              
Dukart, Jürgen2, 6, 7, Author              
Villringer, Arno2, 3, 4, Author              
Affiliations:
1Department of Psychology, University of Haifa, Israel, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
4Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Machine Learning, TU Berlin, Germany, ou_persistent22              
6Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
7Pharma Research and Early Development, F. Hoffmann-La Roche, Basel, Switzerland, ou_persistent22              

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 Abstract: This study investigated the neural regions involved in blood pressure reactions to negative stimuli and their possible modulation by attention. Twenty-four healthy human subjects (11 females; age = 24.75 ± 2.49 years) participated in an affective perceptual load task that manipulated attention to negative/neutral distractor pictures. fMRI data were collected simultaneously with continuous recording of peripheral arterial blood pressure. A parametric modulation analysis examined the impact of attention and emotion on the relation between neural activation and blood pressure reactivity during the task. When attention was available for processing the distractor pictures, negative pictures resulted in behavioral interference, neural activation in brain regions previously related to emotion, a transient decrease of blood pressure, and a positive correlation between blood pressure response and activation in a network including prefrontal and parietal regions, the amygdala, caudate, and mid-brain. These effects were modulated by attention; behavioral and neural responses to highly negative distractor pictures (compared with neutral pictures) were smaller or diminished, as was the negative blood pressure response when the central task involved high perceptual load. Furthermore, comparing high and low load revealed enhanced activation in frontoparietal regions implicated in attention control. Our results fit theories emphasizing the role of attention in the control of behavioral and neural reactions to irrelevant emotional distracting information. Our findings furthermore extend the function of attention to the control of autonomous reactions associated with negative emotions by showing altered blood pressure reactions to emotional stimuli, the latter being of potential clinical relevance.

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Language(s): eng - English
 Dates: 2014-01-122013-02-282014-01-202014-03-19
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.0747-13.2014
PMID: 24647945
 Degree: -

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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 34 (12) Sequence Number: - Start / End Page: 4251 - 4259 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187