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  Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein.

Chua, J. J. E., Bhuvanakantham, R., Chow, V. T. K., & Ng, M. L. (2005). Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Virus Research, 112(1-2), 85-94. doi:10.1016/j.virusres.2005.03.025.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-0A99-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C5B7-6
Genre: Journal Article

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1952166.pdf (Publisher version), 331KB
 
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 Creators:
Chua, J. J. E.1, Author              
Bhuvanakantham, R., Author
Chow, V. T. K., Author
Ng, M. L., Author
Affiliations:
1Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society, ou_1933287              

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Free keywords: Dengue virus; Flaviviruses; Non-structural 1 protein; Human STAT3β protein; Protein–protein interaction; Yeast 2-hybrid
 Abstract: A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3β (ΔN40-STAT3β) protein. The NS1 protein interacted with the activated STAT3β protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6). Since the STAT3β protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome.

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Language(s): eng - English
 Dates: 2005-09
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.virusres.2005.03.025
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Title: Virus Research
Source Genre: Journal
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Pages: - Volume / Issue: 112 (1-2) Sequence Number: - Start / End Page: 85 - 94 Identifier: -