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  Neural correlates of empathic impairment in the behavioral variant of frontotemporal dementia

Cerami, C., Dodich, A., Canessa, N., Crespi, C., Marcone, A., Cortese, F., et al. (2014). Neural correlates of empathic impairment in the behavioral variant of frontotemporal dementia. Alzheimer's and Dementia, 10(6), 827-834. doi:10.1016/j.jalz.2014.01.005.

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Cerami, Chiara1, 2, Autor
Dodich, Alessandra1, 2, Autor
Canessa, Nicola1, 2, Autor
Crespi, Chiara1, 2, Autor
Marcone, Alessandra2, Autor
Cortese, Francesca1, Autor
Chierchia, Gabriele1, Autor           
Scola, Elisa1, 3, Autor
Falini, Andrea1, 3, Autor
Cappa, Stefano A.1, 2, Autor
Affiliations:
1Vita-Salute San Raffaele University, Milan, Italy, ou_persistent22              
2Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy, ou_persistent22              
3CERMAC, San Raffaele Scientific Institute, Milan, Italy, ou_persistent22              

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Schlagwörter: Behavioral variant of frontotemporal dementia; Empathy; Mentalizing; Social cognition disorders; Voxel-based morphometry
 Zusammenfassung: Objective

Loss of empathy is a symptom of the behavioral variant of frontotemporal dementia (bvFTD), constituting a clue for early diagnosis. In this study, we directly compared two empathy components (intention attribution [IA] and emotion attribution [EA]), correlating them with possible specific patterns of gray-matter density reduction within the mentalizing network.
Methods

We evaluated IA and EA in 18 mild bvFTD patients compared with 36 healthy controls (HCs) using a single nonverbal test. A subgroup entered a voxel-based morphometry study.
Results

Compared with HC, bvFTD patients showed IA and EA impairments. EA performance correlated with gray-matter reduction in the right amygdala, left insula, and posterior-superior temporal sulcus extending into the temporoparietal junction.
Conclusion

We proved an empathic impairment, with the ability to infer emotional states showing the most severe deficit. These results provide further evidence of selective disease-specific vulnerability of the limbic and frontoinsular network in bvFTD and highlight the usefulness of empathy assessment in early patients.

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Sprache(n): eng - English
 Datum: 2014-02-282014-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.jalz.2014.01.005
PMID: 24589435
Anderer: Epub 2014
 Art des Abschluß: -

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Titel: Alzheimer's and Dementia
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: New York, NY, USA : Elsevier
Seiten: - Band / Heft: 10 (6) Artikelnummer: - Start- / Endseite: 827 - 834 Identifikator: ISSN: 1552-5260
CoNE: https://pure.mpg.de/cone/journals/resource/1552-5260