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  Neural correlates of empathic impairment in the behavioral variant of frontotemporal dementia

Cerami, C., Dodich, A., Canessa, N., Crespi, C., Marcone, A., Cortese, F., et al. (2014). Neural correlates of empathic impairment in the behavioral variant of frontotemporal dementia. Alzheimer's and Dementia, 10(6), 827-834. doi:10.1016/j.jalz.2014.01.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-51D6-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7EF7-A
Genre: Journal Article

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 Creators:
Cerami, Chiara1, 2, Author
Dodich, Alessandra1, 2, Author
Canessa, Nicola1, 2, Author
Crespi, Chiara1, 2, Author
Marcone, Alessandra2, Author
Cortese, Francesca1, Author
Chierchia, Gabriele1, Author              
Scola, Elisa1, 3, Author
Falini, Andrea1, 3, Author
Cappa, Stefano A.1, 2, Author
Affiliations:
1Vita-Salute San Raffaele University, Milan, Italy, ou_persistent22              
2Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy, ou_persistent22              
3CERMAC, San Raffaele Scientific Institute, Milan, Italy, ou_persistent22              

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Free keywords: Behavioral variant of frontotemporal dementia; Empathy; Mentalizing; Social cognition disorders; Voxel-based morphometry
 Abstract: Objective Loss of empathy is a symptom of the behavioral variant of frontotemporal dementia (bvFTD), constituting a clue for early diagnosis. In this study, we directly compared two empathy components (intention attribution [IA] and emotion attribution [EA]), correlating them with possible specific patterns of gray-matter density reduction within the mentalizing network. Methods We evaluated IA and EA in 18 mild bvFTD patients compared with 36 healthy controls (HCs) using a single nonverbal test. A subgroup entered a voxel-based morphometry study. Results Compared with HC, bvFTD patients showed IA and EA impairments. EA performance correlated with gray-matter reduction in the right amygdala, left insula, and posterior-superior temporal sulcus extending into the temporoparietal junction. Conclusion We proved an empathic impairment, with the ability to infer emotional states showing the most severe deficit. These results provide further evidence of selective disease-specific vulnerability of the limbic and frontoinsular network in bvFTD and highlight the usefulness of empathy assessment in early patients.

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Language(s): eng - English
 Dates: 2014-02-282014-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.jalz.2014.01.005
PMID: 24589435
Other: Epub 2014
 Degree: -

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Title: Alzheimer's and Dementia
Source Genre: Journal
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Publ. Info: New York, NY, USA : Elsevier
Pages: - Volume / Issue: 10 (6) Sequence Number: - Start / End Page: 827 - 834 Identifier: ISSN: 1552-5260
CoNE: https://pure.mpg.de/cone/journals/resource/1552-5260