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  Structure-function relationships of ErbB RTKs in the plasma membrane of living cells

Arndt-Jovin, D. J., Gralle Botelho, M., & Jovin, T. M. (2014). Structure-function relationships of ErbB RTKs in the plasma membrane of living cells. In J. Schlessinger, & M. A. Lemmon (Eds.), Signaling by Receptor Tyrosine Kinases. A subject collection from Cold Spring Harbor Perspectives in Biology (4, pp. 193-206). Cold Spring Harbor, N.Y.: Cold Spring Harbor Lab. Pr.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-6FC0-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-CC35-0
Genre: Book Chapter

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 Creators:
Arndt-Jovin, D. J.1, Author           
Gralle Botelho, M., Author
Jovin, T. M.1, Author           
Affiliations:
1Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578629              

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 Abstract: We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conformational features of the receptors situated in the plasma membrane, compared to the crystallographic structures of the isolated extracellular domains; (3) coupling of receptor disposition on filopodia with the transduction of signaling ligand gradients; and (4) ligand-independent receptor activation by application of a magnetic field.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1101/cshperspect.a008961
 Degree: -

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Title: Signaling by Receptor Tyrosine Kinases. A subject collection from Cold Spring Harbor Perspectives in Biology
Source Genre: Book
 Creator(s):
Schlessinger, J., Editor
Lemmon, M. A., Editor
Affiliations:
-
Publ. Info: Cold Spring Harbor, N.Y. : Cold Spring Harbor Lab. Pr., 4
Pages: 478 Volume / Issue: 6 Sequence Number: - Start / End Page: 193 - 206 Identifier: ISBN: 978-1-936113-33-0