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  Grammar learning in older adults is linked to white matter microstructure and functional connectivity

Antonenko, D., Meinzer, M., Lindenberg, R., Witte, V., & Flöel, A. (2012). Grammar learning in older adults is linked to white matter microstructure and functional connectivity. NeuroImage, 62(3), 1667-1674. doi:10.1016/j.neuroimage.2012.05.074.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-966D-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B030-F
Genre: Journal Article

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 Creators:
Antonenko, Daria1, 2, 3, Author
Meinzer, Marcus1, 2, 3, Author
Lindenberg, Robert1, 2, 3, Author
Witte, Veronica1, 2, 3, Author              
Flöel, Agnes1, 2, 3, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
3Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Diffusion tensor imaging; Fractional anisotropy; Probabilistic tractography; Resting-state functional connectivity; Artificial grammar learning
 Abstract: Age-related decline in cognitive function has been linked to alterations of white matter and functional brain connectivity. With regard to language, aging has been shown to be associated with impaired syntax processing, but the underlying structural and functional correlates are poorly understood. In the present study, we used an artificial grammar learning (AGL) task to determine the ability to extract grammatical rules from new material in healthy older adults. White matter microstructure and resting-state functional connectivity (FC) of task-relevant brain regions were assessed using multimodal magnetic resonance imaging (MRI). AGL performance correlated positively with fractional anisotropy (FA) underlying left and right Brodmann areas (BA) 44/45 and in tracts originating from left BA 44/45. An inverse relationship was found between task performance and FC of left and right BA 44/45, linking lower performance to stronger inter-hemispheric functional coupling. Our results suggest that white matter microstructure underlying specific prefrontal regions and their functional coupling affect acquisition of syntactic knowledge in the aging brain, offering further insight into mechanisms of functional decline in older adults.

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Language(s): eng - English
 Dates: 2012-05-272012-05-312012-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2012.05.074
PMID: 22659480
Other: Epub 2012
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 62 (3) Sequence Number: - Start / End Page: 1667 - 1674 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166