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  Regional sex differences in grey matter volume are associated with sex hormones in the young adult human brain

Witte, V., Savli, M., Holik, A., Kasper, S., & Lanzenberger, R. (2010). Regional sex differences in grey matter volume are associated with sex hormones in the young adult human brain. NeuroImage, 49(2), 1205-1212. doi:10.1016/j.neuroimage.2009.09.046.

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 Creators:
Witte, Veronica1, Author              
Savli, Markus1, Author
Holik, Alexander1, Author
Kasper, Siegfried1, Author
Lanzenberger, Rupert1, Author
Affiliations:
1Functional NeuroImaging Unit - PET & fMRI, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria, ou_persistent22              

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Free keywords: Voxel-based morphometry; 17β-Estradiol; Progesterone; Testosterone; Sex dimorphism; Neural plasticity
 Abstract: Previous studies suggest organizing effects of sex hormones on brain structure during early life and puberty, yet little is known about the adult period. The aim of the present study was to elucidate the role of 17β-estradiol, progesterone, and testosterone on cortical sex differences in grey matter volume (GM) of the adult human brain. To assess sexual dimorphism, voxel-based morphometry (VBM) was applied on structural magnetic resonance images of 34 healthy, young adult humans (17 women, 17 men, 26.6 ± 5 years) using analyses of covariance. Subsequently, circulating levels of sex hormones were associated with regional GM using linear regression analyses. After adjustment for sex and total GM, significant associations of regional GM and 17β-estradiol were observed in the left inferior frontal gyrus (β = 0.39, p = 0.02). Regional GM was inversely associated with testosterone in the left inferior frontal gyrus (β = −0.16, p = 0.04), and with progesterone in the right temporal pole (β = −0.39, p = 0.008). Our findings indicate that even in young adulthood, sex hormones exert organizing effects on regional GM. This might help to shed further light on the underlying mechanisms of both functional diversities and congruence between female and male brains.

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Language(s): eng - English
 Dates: 2009-09-042009-03-242009-09-222009-09-282010-01-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2009.09.046
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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 49 (2) Sequence Number: - Start / End Page: 1205 - 1212 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166