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  Caloric restriction improves memory in elderly humans

Witte, V., Fobker, M., Gellner, R., Knecht, S., & Flöel, A. (2009). Caloric restriction improves memory in elderly humans. Proceedings of the National Academy of Sciences of the United States of America, 106(4), 1255-1260. doi:10.1073/pnas.0808587106.

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 Creators:
Witte, Veronica1, Author              
Fobker, M.2, Author
Gellner, R.3, Author
Knecht, S.1, Author
Flöel, A.1, 4, Author
Affiliations:
1Department of Neurology, University of Münster, Germany, ou_persistent22              
2Department of Internal Medicine, University of Münster, Germany, ou_persistent22              
3Center for Laboratory Medicine, University of Münster, Germany, ou_persistent22              
4Interdisciplinary Center of Clinical Research, University of Münster, Germany, ou_persistent22              

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Free keywords: Aging; Cognition; Diet; Unsaturated fatty acids
 Abstract: Animal studies suggest that diets low in calories and rich in unsaturated fatty acids (UFA) are beneficial for cognitive function in age. Here, we tested in a prospective interventional design whether the same effects can be induced in humans. Fifty healthy, normal- to overweight elderly subjects (29 females, mean age 60.5 years, mean body mass index 28 kg/m2) were stratified into 3 groups: (i) caloric restriction (30% reduction), (ii) relative increased intake of UFAs (20% increase, unchanged total fat), and (iii) control. Before and after 3 months of intervention, memory performance was assessed under standardized conditions. We found a significant increase in verbal memory scores after caloric restriction (mean increase 20%; P < 0.001), which was correlated with decreases in fasting plasma levels of insulin and high sensitive C-reactive protein, most pronounced in subjects with best adherence to the diet (all r values < −0.8; all P values <0.05). Levels of brain-derived neurotrophic factor remained unchanged. No significant memory changes were observed in the other 2 groups. This interventional trial demonstrates beneficial effects of caloric restriction on memory performance in healthy elderly subjects. Mechanisms underlying this improvement might include higher synaptic plasticity and stimulation of neurofacilitatory pathways in the brain because of improved insulin sensitivity and reduced inflammatory activity. Our study may help to generate novel prevention strategies to maintain cognitive functions into old age.

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Language(s): eng - English
 Dates: 2009-01-27
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.0808587106
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Affiliations:
Publ. Info: National Academy of Sciences
Pages: - Volume / Issue: 106 (4) Sequence Number: - Start / End Page: 1255 - 1260 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230