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  Synapse plasticity in motor, sensory, and limbo-prefrontal cortex areas as measured by degrading axon terminals in an environment model of gerbils (Meriones unguiculatus)

Neufeld, J., Teuchert-Noodt, G., Grafen, K., Winter, Y., & Witte, V. (2009). Synapse plasticity in motor, sensory, and limbo-prefrontal cortex areas as measured by degrading axon terminals in an environment model of gerbils (Meriones unguiculatus). Neural Plasticity, 281561. doi:10.1155/2009/281561.

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Neufeld, Janina1, Author
Teuchert-Noodt, Gertraud1, Author
Grafen, Keren1, Author
Winter, York2, 3, Author
Witte, Veronica4, Author           
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1Department of Biology and Neuroanatomy, Bielefeld University, Germany, ou_persistent22              
2Department of Biology, Humboldt University, Berlin, Germany, ou_persistent22              
3NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              

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 Abstract: Still little is known about naturally occurring synaptogenesis in the adult neocortex and related impacts of epigenetic influences. We therefore investigated (pre)synaptic plasticity in various cortices of adult rodents, visualized by secondary lysosome accumulations (LA) in remodeling axon terminals. Twenty-two male gerbils from either enriched (ER) or impoverished rearing (IR) were used for quantification of silver-stained LA. ER-animals showed rather low LA densities in most primary fields, whereas barrel and secondary/associative cortices exhibited higher densities and layer-specific differences. In IR-animals, these differences were evened out or even inverted. Basic plastic capacities might be linked with remodeling of local intrinsic circuits in the context of cortical map adaptation in both IR- and ER-animals. Frequently described disturbances due to IR in multiple corticocortical and extracortical afferent systems, including the mesocortical dopamine projection, might have led to maladaptations in the plastic capacities of prefronto-limbic areas, as indicated by different LA densities in IR- compared with ER-animals.

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Language(s): eng - English
 Dates: 2009-04-202009-06-262009
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1155/2009/281561
PMC: PMC2754524
PMID: 19809517
Other: Epub 2009
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Title: Neural Plasticity
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: 281561 Start / End Page: - Identifier: -