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  Developmental pattern changes of prefrontal efferents in the juvenile gerbil (Meriones unguiculatus)

Witte, V., Brummelte, S., & Teuchert-Noodt, G. (2007). Developmental pattern changes of prefrontal efferents in the juvenile gerbil (Meriones unguiculatus). Journal of Neural Transmission, 114(11), 1377-1393. doi:10.1007/s00702-007-0761-1.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-957C-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CB9C-9
Genre: Journal Article

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 Creators:
Witte, Veronica1, Author              
Brummelte, S.1, Author
Teuchert-Noodt, G.1, Author
Affiliations:
1Department of Neuroanatomy, Faculty of Biology, University of Bielefeld, Germany, ou_persistent22              

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Free keywords: Glutamate; Prefrontal cortex; Biocytin; Cortico-cortical connections
 Abstract: Previous findings of our group showed that early traumatisation leads to a dysfunctional organisation of prefrontocortical efferents in adulthood. To identify vulnerable time windows during maturation, we labelled either layer III- or layer V/VI-pyramidal cells with biocytin in the prefrontal cortex of gerbils (Meriones unguiculatus) from the age of postnatal day (PD) 15 up to adulthood (PD 90). The density of passing fibres and axonal terminals in distinct cortical columns in specific prefrontal projection areas was assessed by digital image analysis. Following layer III injections, fibre densities reached adult values between adolescence (PD 60) and adulthood (PD 90). However, layer V/VI-fibre densities decreased after eye-opening (PD 15), followed by an increase to adult values after weaning (PD 30). These findings are the first to describe dynamic structural changes even beyond adolescence of functionally diverse prefrontal output systems. External interventions might exert adverse influences on the establishment of integrated prefrontal networks especially during the early phase of re-arranging.

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Language(s): eng - English
 Dates: 2007-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s00702-007-0761-1
 Degree: -

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Title: Journal of Neural Transmission
  Other : J. Neural Transm.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Wien : Springer-Verlag.
Pages: - Volume / Issue: 114 (11) Sequence Number: - Start / End Page: 1377 - 1393 Identifier: ISSN: 0300-9564
CoNE: https://pure.mpg.de/cone/journals/resource/991042725899232