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  Postnatal development of GABA and calbindin cells and fibers in the prefrontal cortex and basolateral amygdala of gerbils (Meriones unguiculatus)

Brummelte, S., Witte, V., & Teuchert-Noodt, G. (2007). Postnatal development of GABA and calbindin cells and fibers in the prefrontal cortex and basolateral amygdala of gerbils (Meriones unguiculatus). International Journal of Developmental Neuroscience, 25(3), 191-200. doi:10.1016/j.ijdevneu.2007.01.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-9572-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-CB9D-7
Genre: Journal Article

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Brummelte, Susanne1, Author
Witte, Veronica1, Author              
Teuchert-Noodt, Gertraud1, Author
Affiliations:
1Department of Neuroanatomy, Faculty of Biology, University of Bielefeld, Germany, ou_persistent22              

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Free keywords: Gamma-amino-butyric acid; Calbindin; Calcium-binding proteins; Immunohistochemistry; Development; Limbic system
 Abstract: The postnatal maturation of immunohistochemically stained gamma-amino-butyric acid (GABA) and calbindin (CB) cells and fibers were quantitatively examined in the prefrontal cortex (PFC) and the basolateral amygdala (BLA) of the Mongolian gerbil (Meriones unguiculatus). Animals of different ages, ranging from juvenile (postnatal day (PD)14, PD20, PD30), to adolescent (PD70), adult (PD180, PD540) and aged (PD720) were analyzed. Results reveal an increase in GABAergic fiber densities between PD14-20 in the PFC and the BLA with a concomitant decrease in cell density. After PD70 GABA fiber density slightly decreases again in the BLA, while there is a further slow but significant increase in the PFC between PD70 and PD540. Fibers immunoreactive for the calcium binding-protein CB, which is predominantly localized in particular GABAergic subpopulations, also accumulate between PD14 and PD20 in the PFC and BLA, while a concomitant decrease in cell density is only seen in the BLA. Both areas reveal a decrease of CB cells between PD30 and PD70, which parallels with a decrease of CB fibers in the PFC. However, there is no particular ‘aging-effect’ in the fiber or cell densities of GABA or CB in any of the investigated areas in old animals. In conclusion, we here demonstrate long-term dynamics in cell and fiber densities of the GABAergic system until late in development which might correspond to the prolonged maturation of other neuroanatomical and functional systems.

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Language(s): eng - English
 Dates: 2007-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.ijdevneu.2007.01.002
 Degree: -

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Title: International Journal of Developmental Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 25 (3) Sequence Number: - Start / End Page: 191 - 200 Identifier: ISSN: 0736-5748
CoNE: https://pure.mpg.de/cone/journals/resource/954925536103