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  Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T

Huber, L., Goense, J., Kennerley, A. J., Ivanov, D., Krieger, S., Lepsien, J., et al. (2014). Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T. NeuroImage, 97, 349-362. doi:10.1016/j.neuroimage.2014.04.022.

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Huber, Laurentius1, Autor           
Goense, Jozien2, Autor
Kennerley, Aneurin J.3, Autor
Ivanov, Dimo4, Autor
Krieger, Steffen5, 6, Autor           
Lepsien, Jöran1, Autor           
Trampel, Robert5, Autor           
Turner, Robert5, Autor           
Möller, Harald E.1, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom, ou_persistent22              
3Signal Processing in Neuroimaging and Systems Neuroscience, University of Sheffield, United Kingdom, ou_persistent22              
4Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
5Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
6Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia, ou_persistent22              

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Schlagwörter: Vascular space occupancy; SS-SI-VASO; Cerebral blood volume; Negative BOLD response; 7 Tesla MRI; Vascular compartments
 Zusammenfassung: Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7 T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in ‘arterial’ and ‘venous’ blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between ‘arterial’ and ‘venous’ contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms.

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Sprache(n): eng - English
 Datum: 2014-04-072014-04-152014-08-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2014.04.022
PMID: 24742920
Anderer: Epub 2014
 Art des Abschluß: -

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 97 Artikelnummer: - Start- / Endseite: 349 - 362 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166