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  Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T

Huber, L., Goense, J., Kennerley, A. J., Ivanov, D., Krieger, S., Lepsien, J., et al. (2014). Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T. NeuroImage, 97, 349-362. doi:10.1016/j.neuroimage.2014.04.022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-C72E-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-826D-0
Genre: Journal Article

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 Creators:
Huber, Laurentius1, Author              
Goense, Jozien2, Author
Kennerley, Aneurin J.3, Author
Ivanov, Dimo4, Author
Krieger, Steffen5, 6, Author              
Lepsien, Jöran1, Author              
Trampel, Robert5, Author              
Turner, Robert5, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom, ou_persistent22              
3Signal Processing in Neuroimaging and Systems Neuroscience, University of Sheffield, United Kingdom, ou_persistent22              
4Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
5Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
6Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia, ou_persistent22              

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Free keywords: Vascular space occupancy; SS-SI-VASO; Cerebral blood volume; Negative BOLD response; 7 Tesla MRI; Vascular compartments
 Abstract: Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7 T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in ‘arterial’ and ‘venous’ blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between ‘arterial’ and ‘venous’ contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms.

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Language(s): eng - English
 Dates: 2014-04-072014-04-152014-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2014.04.022
PMID: 24742920
Other: Epub 2014
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 97 Sequence Number: - Start / End Page: 349 - 362 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166