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  LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells

Fogeron, M.-L., Müller, H., Schade, S., Dreher, F., Lehmann, V., Kühnel, A., et al. (2013). LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nature Communications, 4, 4:1531-4:1531. doi:10.1038/Ncomms2517.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-D743-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-CA94-6
Genre: Journal Article

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 Creators:
Fogeron, M.-L.1, Author              
Müller, H.2, Author
Schade, S.1, Author              
Dreher, F.3, Author              
Lehmann, V.1, Author
Kühnel, A.1, Author
Scholz, A. K.4, Author              
Kashofer, K., Author
Zerck, A.1, Author              
Fauler, B.5, Author
Lurz, R.5, Author              
Herwig, R.3, Author              
Zatloukal, K., Author
Lehrach, H.1, Author              
Gobom, J.1, Author              
Nordhoff, E.1, Author              
Lange, B.1, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2AG Müller, Marianne, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society, ou_1607153              
3Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              
4• Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
5Imaging/Electron Microscopy (Head: Rudi Lurz/Thorsten Mielke), Scientific Service (Head: Manuela B. Urban), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479668              

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Free keywords: mac-2 binding-protein ring-like structures gamma-tubulin cycle disease complex instability tumors identification cytoskeletal
 Abstract: Centrosome morphology and number are frequently deregulated in cancer cells. Here, to identify factors that are functionally relevant for centrosome abnormalities in cancer cells, we established a protein-interaction network around 23 centrosomal and cell-cycle regulatory proteins, selecting the interacting proteins that are deregulated in cancer for further studies. One of these components, LGALS3BP, is a centriole-and basal body-associated protein with a dual role, triggering centrosome hypertrophy when overexpressed and causing accumulation of centriolar substructures when downregulated. The cancer cell line SK-BR-3 that overexpresses LGALS3BP exhibits hypertrophic centrosomes, whereas in seminoma tissues with low expression of LGALS3BP, supernumerary centriole-like structures are present. Centrosome hypertrophy is reversed by depleting LGALS3BP in cells endogenously over-expressing this protein, supporting a direct role in centrosome aberration. We propose that LGALS3BP suppresses assembly of centriolar substructures, and when depleted, causes accumulation of centriolar complexes comprising CPAP, acetylated tubulin and centrin.

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Language(s): eng - English
 Dates: 2012-05-172013-01-172013-02-262013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: Other: WOS:000316616400099
DOI: 10.1038/Ncomms2517
ISSN: 2041-1723
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 4 Sequence Number: - Start / End Page: 4:1531 - 4:1531 Identifier: ISSN: 2041-1723
CoNE: /journals/resource/2041-1723