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  Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

Hartl, D., Klatt, S., Roch, M., Konthur, Z., Klose, J., Willnow, T. E., et al. (2013). Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons. PLoS One, 8(6). doi:ARTN e65920DOI 10.1371/journal.pone.0065920.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-DE65-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-DE67-F
Genre: Journal Article

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2013
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2013 Hartl et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 Creators:
Hartl, D., Author
Klatt, S.1, Author              
Roch, M., Author
Konthur, Z.1, 2, Author              
Klose, J., Author
Willnow, T. E., Author
Rohe, M., Author
Affiliations:
1Zoltán Konthur, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863499              
2Max Planck Institute of Colloids and Interfaces , Potsdam, Germany, ou_persistent22              

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Free keywords: amyloid precursor protein cyclin-dependent kinase-5 sortilin-related receptor alzheimers-disease hippocampal-neurons secreted forms neurodegenerative diseases tau phosphorylation cerebrospinal-fluid adult neurogenesis
 Abstract: A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties. However, it remained enigmatic what proteins, targeted by sAPPalpha, might be involved in such neuroprotective actions. Here, we used high-resolution two-dimensional polyacrylamide gel electrophoresis to analyze proteome changes downstream of sAPPalpha in neurons. We present evidence that sAPPalpha regulates expression and activity of CDK5, a kinase that plays an important role in AD pathology. We also identified the cytoprotective chaperone ORP150 to be induced by sAPPalpha as part of this protective response. Finally, we present functional evidence that the sAPPalpha receptor SORLA is essential to mediate such molecular functions of sAPPalpha in neurons.

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Language(s): eng - English
 Dates: 2013-02-262013-04-292013-07-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000320755400080
DOI: ARTN e65920DOI 10.1371/journal.pone.0065920
ISSN: 1932-6203
URI: ://WOS:000320755400080http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0065920&representation=PDF
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (6) Sequence Number: - Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850