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  Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response

Krüger, A., Vowinckel, J., Mulleder, M., Grote, P., Capuano, F., Bluemlein, K., et al. (2013). Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response. EMBO Reports, 14(12), 1113-9. doi:10.1038/embor.2013.165.

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This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. To view a copy of this licence visit http://creativecommons.org/licenses/by/3.0/.
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2013
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2013 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION

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Krüger, A., Author
Vowinckel, J., Author
Mulleder, M., Author
Grote, P.1, Author           
Capuano, F., Author
Bluemlein, K., Author
Ralser, M., Author
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: Cells counteract oxidative stress by altering metabolism, cell cycle and gene expression. However, the mechanisms that coordinate these adaptations are only marginally understood. Here we provide evidence that timing of these responses in yeast requires export of the polyamines spermidine and spermine. We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Moreover, Tpo1 determines a cell cycle delay during adaptation to increased oxidant levels, and affects H2O2 tolerance. Thus, central components of the stress response are timed through Tpo1-controlled polyamine export.

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 Dates: 2013-09-202013-08-292013-09-202013-10-182013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 24136413
DOI: 10.1038/embor.2013.165
ISSN: 1469-3178 (Electronic)1469-221X (Linking)
URI: http://www.ncbi.nlm.nih.gov/pubmed/24136413http://embor.embopress.org/content/embor/14/12/1113.full.pdf
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Title: EMBO Reports
  Other : EMBO Rep.
Source Genre: Journal
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Publ. Info: Oxford, UK : Published for EMBO by Oxford University Press
Pages: - Volume / Issue: 14 (12) Sequence Number: - Start / End Page: 1113 - 9 Identifier: ISSN: 1469-221X
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569661