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  Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory

Li, S. C., Papenberg, G., Nagel, I. E., Preuschhof, C., Schröder, J., Nietfeld, W., et al. (2013). Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory. Neurobiology of Aging, 34(1), 358.e1-358.e10. doi:Artn 358.E1Doi 10.1016/J.Neurobiolaging.2012.08.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-028A-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-028C-D
Genre: Journal Article

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2013
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2013 Elsevier Inc. All rights reserved.
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 Creators:
Li, S. C., Author
Papenberg, G., Author
Nagel, I. E., Author
Preuschhof, C., Author
Schröder, J.1, Author
Nietfeld, W.1, Author              
Bertram, L.2, Author              
Heekeren, H. R., Author
Lindenberger, U., Author
Backman, L., Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

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Free keywords: aging dopamine genetics dat slc6a3 drd2 episodic memory serial recall bdnf val66met polymorphism short-term-memory working-memory c957t polymorphism in-vivo prefrontal neurons episodic memory human striatum human brain recall
 Abstract: Aging compromises dopamine transporter (DAT) and receptor mechanisms in the frontostriatal circuitry. In a sample of 1288 younger and older adults, we investigated (i) whether individual differences in genotypes of the DAT gene (i. e., SLC6A3, the DAT variable number of tandem repeat 9/9, 9/10, and 10/10) and in the D2 receptor (DRD2) gene (i. e., the C957T [rs6277] CC and any T) interactively contribute to phenotype variations in episodic memory performance; and (ii) whether these genetic effects are magnified in older adults, because of considerable declines in the dopamine functions. Our results showed that carrying genotypes associated with higher levels of striatal synaptic dopamine (DAT 9/9) and higher density of extrastriatal D2 receptors (C957T CC) were associated with better backward serial recall, an episodic memory task with high encoding and retrieval demands. Critically, the gene-gene interaction effect was reliably stronger in older than in younger adults. In line with the resource modulation hypothesis, our findings suggest that aging-related decline in brain phenotypes (e. g., dopamine functions) could alter the relations between genotypes and behavioral phenotypes (e. g., episodic memory). (C) 2013 Elsevier Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2013-01-012013
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000311026700035
DOI: Artn 358.E1Doi 10.1016/J.Neurobiolaging.2012.08.001
ISSN: 0197-4580
URI: ://WOS:000311026700035http://ac.els-cdn.com/S019745801200423X/1-s2.0-S019745801200423X-main.pdf?_tid=66b80826-bb17-11e3-bd7a-00000aab0f26&acdnat=1396519673_2233f71bd9101ebd41a7e91e36a81334
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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 34 (1) Sequence Number: - Start / End Page: 358.e1 - 358.e10 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902