English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials

Li, S. C., Passow, S., Nietfeld, W., Schröder, J., Bertram, L., Heekeren, H. R., et al. (2013). Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials. Neuropsychologia, 51(8), 1649-1661. doi:DOI 10.1016/j.neuropsychologia.2013.04.005.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0217-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-021A-F
Genre: Journal Article

Files

show Files
hide Files
:
Li.pdf (Publisher version), 3MB
 
File Permalink:
-
Name:
Li.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Molecular Genetics, MBMG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
2013
Copyright Info:
2013 Elsevier Ltd. All rights reserved.
License:
-

Locators

show

Creators

show
hide
 Creators:
Li, S. C.1, Author
Passow, S., Author
Nietfeld, W.2, Author              
Schröder, J.2, Author
Bertram, Lars3, Author              
Heekeren, H. R., Author
Lindenberger, U.1, Author
Affiliations:
1Max Planck Institute for Human Development, Lentzallee 49, D-14195 Berlin, Germany,, ou_persistent22              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
3Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

Content

show
hide
Free keywords: attention selective attention conflict monitoring auditory processing dopamine evoked potentials darpp-32 ppp1r1b predict individual-differences deficit hyperactivity disorder temporally selective attention event-related potentials striatal dopamine prefrontal cortex working-memory deficit/hyperactivity disorder basal ganglia stroop task
 Abstract: Using a specific variant of the dichotic listening paradigm, we studied the influence of dopamine on attentional modulation of auditory perception by assessing effects of allelic variation of a single-nucleotide polymorphism (SNP) rs907094 in the DARPP-32 gene (dopamine and adenosine 3', 5'-monophosphate-regulated phosphoprotein 32 kilodations; also known as PPP1R1B) on behavior and cortical evoked potentials. A frequent DARPP-32 haplotype that includes the A allele of this SNP is associated with higher mRNA expression of DARPP-32 protein isoforms, striatal dopamine receptor function, and frontal striatal connectivity. As we hypothesized, behaviorally the A homozygotes were more flexible in selectively attending to auditory inputs than any G carriers. Moreover, this genotype also affected auditory evoked cortical potentials that reflect early sensory and late attentional processes. Specifically, analyses of event-related potentials (ERPs) revealed that amplitudes of an early component of sensory selection (N1) and a late component (N450) reflecting attentional deployment for conflict resolution were larger in A homozygotes than in any G carriers. Taken together, our data lend support for dopamine's role in modulating auditory attention both during the early sensory selection and late conflict resolution stages. (C) 2013 Elsevier Ltd. All rights reserved.

Details

show
hide
Language(s): eng - English
 Dates: 2013-03-162012-11-232013-04-162013-04-292013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000321938800029
DOI: DOI 10.1016/j.neuropsychologia.2013.04.005
ISSN: 0028-3932
URI: ://WOS:000321938800029http://ac.els-cdn.com/S0028393213001206/1-s2.0-S0028393213001206-main.pdf?_tid=5dc44a4a-bb17-11e3-8057-00000aacb360&acdnat=1396519658_4f83dbf360c7c271a0604d7e615daf58
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuropsychologia
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Pergamon
Pages: 13 Volume / Issue: 51 (8) Sequence Number: - Start / End Page: 1649 - 1661 Identifier: ISSN: 0028-3932
CoNE: https://pure.mpg.de/cone/journals/resource/954925428258