English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Dopamine and glutamate receptor genes interactively influence episodic memory in old age

Papenberg, G., Li, S. C., Nagel, I. E., Nietfeld, W., Schjeide, B. M., Schröder, J., et al. (2014). Dopamine and glutamate receptor genes interactively influence episodic memory in old age. Neurobiology of Aging, 35(5), 1213.e3-1213.e8. doi:ARTN 1213.e3DOI 10.1016/j.neurobiolaging.2013.11.014.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F9BB-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-AA6A-0
Genre: Journal Article

Files

show Files
hide Files
:
Papenberg.pdf (Publisher version), 294KB
 
File Permalink:
-
Name:
Papenberg.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Molecular Genetics, MBMG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
2014
Copyright Info:
2014 Elsevier Inc.
License:
-

Locators

show

Creators

show
hide
 Creators:
Papenberg, G., Author
Li, S. C., Author
Nagel, I. E., Author
Nietfeld, W.1, Author              
Schjeide, B. M.2, Author              
Schröder, J.1, Author
Bertram, L.2, Author              
Heekeren, Hauke R., Author
Lindenberger, U., Author
Bäckman, L., Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

Content

show
hide
Free keywords: glutamate dopamine episodic memory aging d2 receptors nmda receptors gene-gene interactions methyl-d-aspartate associative-deficit hypothesis long-term potentiation locomotor-activity nmda receptors ca1 region consolidation hippocampus modulation activation
 Abstract: Both the dopaminergic and glutamatergic systems modulate episodic memory consolidation. Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance. Given that individual differences in episodic memory are heritable, we investigated whether variations of the dopamine D2 receptor gene (rs6277, C957T) and the N-methyl-D-aspartate 3A (NR3A) gene, coding for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor (rs10989591, Val362Met), interactively modulate episodic memory in large samples of younger (20-31 years; n = 670) and older (59-71 years; n = 832) adults. We found a reliable gene-gene interaction, which was observed in older adults only: older individuals carrying genotypes associated with greater D2 and N-methyl-D-aspartate receptor efficacy showed better episodic performance. These results are in line with findings showing magnification of genetic effects on memory in old age, presumably as a consequence of reduced brain resources. Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory. (C) 2014 Elsevier Inc. All rights reserved.

Details

show
hide
Language(s): eng - English
 Dates: 2013-08-232013-03-112013-11-152013-11-222014-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: Other: WOS:000332308300032
DOI: ARTN 1213.e3DOI 10.1016/j.neurobiolaging.2013.11.014
ISSN: 0197-4580
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 35 (5) Sequence Number: - Start / End Page: 1213.e3 - 1213.e8 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902