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  Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins

Penkov, D., Mateos San Martin, D., Fernandez-Diaz, L. C., Rossello, C. A., Torroja, C., Sanchez-Cabo, F., et al. (2013). Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins. Cell Reports, 3(4), 1321-33. doi:S2211-1247(13)00136-8 [pii]10.1016/j.celrep.2013.03.029.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F9A7-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F9AA-1
Genre: Journal Article

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Penkov.pdf (Publisher version), 3MB
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2013
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2013 The Authors

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 Creators:
Penkov, D., Author
Mateos San Martin, D., Author
Fernandez-Diaz, L. C., Author
Rossello, C. A., Author
Torroja, C., Author
Sanchez-Cabo, F., Author
Warnatz, H.J.1, Author              
Sultan, M.2, Author              
Yaspo Lehrach, M. L.2, Author              
Gabrieli, A., Author
Tkachuk, V., Author
Brendolan, A., Author
Blasi, F., Author
Torres, M., Author
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Human Chromosome 21 (Marie-Laure Yaspo), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479652              

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Free keywords: Animals Binding Sites DNA/*metabolism Embryo, Mammalian/metabolism Genome Homeodomain Proteins/genetics/*metabolism Mice Neoplasm Proteins/genetics/metabolism Promoter Regions, Genetic Protein Binding Thymocytes/metabolism Transcription Factors/metabolism Transcription Initiation Site
 Abstract: The interactions of Meis, Prep, and Pbx1 TALE homeoproteins with Hox proteins are essential for development and disease. Although Meis and Prep behave similarly in vitro, their in vivo activities remain largely unexplored. We show that Prep and Meis interact with largely independent sets of genomic sites and select different DNA-binding sequences, Prep associating mostly with promoters and housekeeping genes and Meis with promoter-remote regions and developmental genes. Hox target sequences associate strongly with Meis but not with Prep binding sites, while Pbx1 cooperates with both Prep and Meis. Accordingly, Meis1 shows strong genetic interaction with Pbx1 but not with Prep1. Meis1 and Prep1 nonetheless coregulate a subset of genes, predominantly through opposing effects. Notably, the TALE homeoprotein binding profile subdivides Hox clusters into two domains differentially regulated by Meis1 and Prep1. During evolution, Meis and Prep thus specialized their interactions but maintained significant regulatory coordination.

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Language(s): eng - English
 Dates: 2013-04-252013-02-192013-07-182013-03-202013-04-182013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Amsterdam et al : Elsevier
Pages: 14 Volume / Issue: 3 (4) Sequence Number: - Start / End Page: 1321 - 33 Identifier: Other: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247