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  Aging and KIBRA/WWC1 Genotype Affect Spatial Memory Processes in a Virtual Navigation Task

Schuck, N. W., Doeller, C. F., Schjeide, B.-M., Schröder, J., Frensch, P. A., Bertram, L., et al. (2013). Aging and KIBRA/WWC1 Genotype Affect Spatial Memory Processes in a Virtual Navigation Task. Hippocampus, 23(10), 919-930. doi:Doi 10.1002/Hipo.22148.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F956-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F959-8
Genre: Journal Article

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Schuck.pdf (Publisher version), 498KB
 
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2013
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2013 Wiley Periodicals, Inc.
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 Creators:
Schuck, N. W., Author
Doeller, C. F., Author
Schjeide, B.-M.1, Author              
Schröder, J.1, Author
Frensch, P. A., Author
Bertram, L.1, Author              
Li, S. C., Author
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

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Free keywords: spatial navigation hippocampus striatum aging kibra hippocampal place cells caudate-nucleus lesions medial temporal-lobe age-differences water maze geometric determinants val66met polymorphism entorhinal cortex episodic memory sex-differences
 Abstract: Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary-related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to directional and landmark-related information and primarily involves the striatum. Using a virtual reality navigation paradigm, we studied the impacts of aging and a single nucleotide polymorphism (SNP rs17070145) of the KIBRA gene (official name: WWC1) on these memory forms. Our data showed that older adult's spatial learning was preferentially related to processing of landmark information, whereas processing of boundary information played a more prominent role in younger adults. Moreover, among older adults T-allele carriers of the examined KIBRA polymorphism showed better spatial learning compared to C homozygotes. Together these findings provide the first evidence for an effect of the KIBRA rs17070145 polymorphism on spatial memory in humans and age differences in the reliance on landmark and boundary-related spatial information. (c) 2013 Wiley Periodicals, Inc.

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Language(s): eng - English
 Dates: 2013-05-172013-06-262013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000325107900008
DOI: Doi 10.1002/Hipo.22148
ISSN: 1050-9631
URI: ://WOS:000325107900008http://onlinelibrary.wiley.com/store/10.1002/hipo.22148/asset/hipo22148.pdf?v=1&t=htjvmdoq&s=e32546803ea67c98c875b11f8fca78ecfca7fee7
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Title: Hippocampus
Source Genre: Journal
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Publ. Info: New York, N.Y. : Wiley-Liss, Inc.
Pages: 11 Volume / Issue: 23 (10) Sequence Number: - Start / End Page: 919 - 930 Identifier: ISSN: 1050-9631
CoNE: https://pure.mpg.de/cone/journals/resource/954925593481