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  Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning

Schuck, N. W., Frensch, P. A., Schjeide, B. M., Schröder, J., Bertram, L., & Li, S. C. (2013). Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning. Neuropsychologia, 51(13), 2757-2769. doi:DOI 10.1016/j.neuropsychologia.2013.09.009.

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2013
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2014 Elsevier B.V. except certain content provided by third parties. ScienceDirect® is a registered trademark of Elsevier B.V.
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Schuck, N. W., Author
Frensch, P. A., Author
Schjeide, B. M.1, Author              
Schröder, J., Author
Bertram, L.1, Author              
Li, S. C., Author
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

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Free keywords: aging dopamine darpp-32 dat implicit and explicit memory sequence learning serial reaction time task medial temporal-lobe deficit hyperactivity disorder process dissociation procedure serial patterns age-differences older-adults human brain individual-differences striatal contributions concurrent implicit
 Abstract: The striatum and medial temporal lobe play important roles in implicit and explicit memory, respectively. Furthermore, recent studies have linked striatal dopamine modulation to both implicit as well as explicit sequence learning and suggested a potential role of the striatum in the emergence of explicit memory during sequence learning. With respect to aging, previous findings indicated that implicit memory is less impaired than explicit memory in older adults and that genetic effects on cognition are magnified by aging. To understand the links between these findings, we investigated effects of aging and genotypes relevant for striatal dopamine on the implicit and explicit components of sequence learning. Reaction time (RT) and error data from 80 younger (20-30 years) and 70 older adults (60-71 years) during a serial reaction time task showed that age differences in learning-related reduction of RTs emerged gradually over the course of learning. Verbal recall and measures derived from the process-dissociation procedure revealed that younger adults acquired more explicit memory about the sequence than older adults, potentially causing age differences in RT gains in later stages of learning. Of specific interest, polymorphisms of the dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32, rs907094) and dopamine transporter (DAT, VNTR) genes showed interactive effects on overall RTs and verbal recall of the sequence in older but not in younger adults. Together our findings show that variations in genotypes relevant for dopamine functions are associated more with aging-related impairments in the explicit than the implicit component of sequence learning, providing support for theories emphasizing the role of dopaminergic modulation in cognitive aging and the magnification of genetic effects in human aging. (C) 2013 Elsevier Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2013-09-032013-04-092013-09-042013-09-122013
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: Other: WOS:000328869400029
DOI: DOI 10.1016/j.neuropsychologia.2013.09.009
ISSN: 0028-3932
URI: ://WOS:000328869400029http://ac.els-cdn.com/S0028393213002935/1-s2.0-S0028393213002935-main.pdf?_tid=4486e4ca-bb17-11e3-97ff-00000aacb361&acdnat=1396519616_ff08ad4563ff182daf5d9fb2735228fe
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Title: Neuropsychologia
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 51 (13) Sequence Number: - Start / End Page: 2757 - 2769 Identifier: ISSN: 0028-3932
CoNE: https://pure.mpg.de/cone/journals/resource/954925428258