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  Genomics and epigenomics: new promises of personalized medicine for cancer patients

Schweiger, M. R., Barmeyer, C., & Timmermann, B. (2013). Genomics and epigenomics: new promises of personalized medicine for cancer patients. Briefings in Functional Genomics, 12(5), 411-21. doi:10.1093/bfgp/elt024.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F934-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F937-5
Genre: Journal Article

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Schweiger.pdf (Publisher version), 734KB
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2013
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The Author 2013. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com
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 Creators:
Schweiger, M. R.1, Author              
Barmeyer, C., Author
Timmermann, B.2, Author              
Affiliations:
1Cancer Genomics (Michal-Ruth Schweiger), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479649              
2Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Recent years have brought about a marked extension of our understanding of the somatic basis of cancer. Parallel to the large-scale investigation of diverse tumor genomes the knowledge arose that cancer pathologies are most often not restricted to single genomic events. In contrast, a large number of different alterations in the genomes and epigenomes come together and promote the malignant transformation. The combination of mutations, structural variations and epigenetic alterations differs between each tumor, making individual diagnosis and treatment strategies necessary. This view is summarized in the new discipline of personalized medicine. To satisfy the ideas of this approach each tumor needs to be fully characterized and individual diagnostic and therapeutic strategies designed. Here, we will discuss the power of high-throughput sequencing technologies for genomic and epigenomic analyses. We will provide insight into the current status and how these technologies can be transferred to routine clinical usage.

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 Dates: 2013-06-282013
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 23814132
DOI: 10.1093/bfgp/elt024
ISSN: 2041-2657 (Electronic)2041-2649 (Linking)
URI: http://www.ncbi.nlm.nih.gov/pubmed/23814132http://bfg.oxfordjournals.org/content/12/5/411.full.pdf
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Title: Briefings in Functional Genomics
  Other : Special Issue: Insights from genomic analysis of cancer
Source Genre: Journal
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Publ. Info: London : H. Stewart Publications
Pages: 11 Volume / Issue: 12 (5) Sequence Number: - Start / End Page: 411 - 21 Identifier: ISSN: 1467-5463
CoNE: https://pure.mpg.de/cone/journals/resource/974392606063