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  Genomics and epigenomics of colorectal cancer

Schweiger, M.-R., Hussong, M., Roehr, C., & Lehrach, H. (2013). Genomics and epigenomics of colorectal cancer. Wiley Interdisciplinary Reviews: Cognitive Science, 5(2), 205-219. doi:Doi 10.1002/Wsbm.1206.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F8F3-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F8FC-4
Genre: Journal Article

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Schweiger.pdf (Publisher version), 406KB
 
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2013
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2013 Wiley Periodicals, Inc.
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 Creators:
Schweiger, M.-R.1, Author              
Hussong, M.1, Author              
Roehr, C.1, Author              
Lehrach, H.2, Author              
Affiliations:
1Cancer Genomics (Michal-Ruth Schweiger), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479649              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: island methylator phenotype fecal-occult-blood human colon-cancer epithelial-mesenchymal transition histone deacetylase inhibitors tumor-suppressor gene DNA methylation microsatellite-instability adenomatous polyposis stage-ii
 Abstract: Colorectal cancer is one of the most common cancer types worldwide and accounts for approximately 600,000 deaths annually. Work over the last decades has uncovered a number of tumor-suppressor and oncogenes which are frequently mutated and might thus be responsible for the malignant transformation. However, only with the development of new high-throughput technologies systematic analyses of the genome and epigenomes became feasible. While data generation has increased exponential, we are now faced with new challenges to transform these data into useful models that help predicting the outcome of genomic aberrations and to develop novel diagnostic and therapeutic strategies. As a basis for the modeling it is essential to understand and integrate current knowledge. We review previous and current ideas in colorectal cancer development and focus on a pathway oriented view. We show that colorectal cancer is a multilayer complex disease affecting the genome as well as the epigenome with direct consequences on the gene and microRNA (miRNA) expression signatures. The goal is to illustrate the current principles of colorectal cancer pathogenesis and to illustrate the need for elaborate computer modeling systems. WIREs Syst Biol Med 2013, 5:205219. doi: 10.1002/wsbm.1206 For further resources related to this article, please visit the WIREs website.

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Language(s): eng - English
 Dates: 2013-01-162013
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000314176000005
DOI: Doi 10.1002/Wsbm.1206
ISSN: 1939-5094
URI: ://WOS:000314176000005http://onlinelibrary.wiley.com/store/10.1002/wsbm.1206/asset/1206_ftp.pdf?v=1&t=htk691r7&s=47ca2e984c7493e8b0c74246844744aaf9ddefce
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Title: Wiley Interdisciplinary Reviews: Cognitive Science
  Other : Cognitive Science
  Other : WIRES Cognitive Science
  Abbreviation : Wiley Interdiscip Rev Cogn Sci
Source Genre: Journal
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Publ. Info: Malden, MA : Wiley
Pages: - Volume / Issue: 5 (2) Sequence Number: - Start / End Page: 205 - 219 Identifier: Other: 1939-5078
CoNE: https://pure.mpg.de/cone/journals/resource/1939-5078