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  Current methods for inducing pluripotency in somatic cells

Tavernier, G., Mlody, B., Demeester, J., Adjaye, J., & De Smedt, S. C. (2013). Current methods for inducing pluripotency in somatic cells. Advanced Materials, 25(20), 2765-71. doi:10.1002/adma.201204874.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F7AE-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F7B0-1
Genre: Journal Article

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Tavernier.pdf (Publisher version), 222KB
 
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2013
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© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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 Creators:
Tavernier, G., Author
Mlody, B.1, Author              
Demeester, J., Author
Adjaye, J.1, Author              
De Smedt, S. C., Author
Affiliations:
1Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479654              

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Free keywords: Animals Batch Cell Culture Techniques/*trends Cell Culture Techniques/*trends Genetic Engineering/*trends Humans Hybrid Cells/*cytology/*physiology Induced Pluripotent Stem Cells/*cytology/*physiology Tissue Engineering/trends
 Abstract: The groundbreaking discovery of reprogramming fibroblasts towards pluripotency merely by introducing four transcription factors (OCT4, SOX2, KLF4 and c-MYC) by means of retroviral transduction has created a promising revolution in the field of regenerative medicine. These so-called induced pluripotent stem cells (iPSCs) can provide a cell source for disease-modelling, drug-screening platforms, and transplantation strategies to treat incurable degenerative diseases, while circumventing the ethical issues and immune rejections associated with the use of non-autologous embryonic stem cells. The risk of insertional mutagenesis, caused both by the viral and transgene nature of the technique has proven to be the major limitation for iPSCs to be used in a clinical setting. In view of this, a variety of alternative techniques have been developed to induce pluripotency in somatic cells. This review provides an overview on current reprogramming protocols, discusses their pros and cons and future challenges to provide safe and transgene-free iPSCs.

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Language(s): eng - English
 Dates: 2012-11-272013-03-262013-05-28
 Publication Status: Published in print
 Pages: -
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Title: Advanced Materials
  Other : Adv. Mater.
Source Genre: Journal
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Publ. Info: [Deerfield Beach, FL : VCH Publishers]
Pages: 7 Volume / Issue: 25 (20) Sequence Number: - Start / End Page: 2765 - 71 Identifier: ISSN: 0935-9648
CoNE: /journals/resource/954925570855