English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The Gini coefficient: A methodological pilot study to assess fetal brain development employing postmortem diffusion MR

Viehweger, A., Riffert, T., Dhital, B., Knösche, T. R., Anwander, A., Stepan, H., et al. (2014). The Gini coefficient: A methodological pilot study to assess fetal brain development employing postmortem diffusion MR. Pediatric Radiology, 44(10), 1290-1301. doi:10.1007/s00247-014-3002-4.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-D830-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-14FF-8
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Viehweger, Adrian1, Author
Riffert, Till2, Author              
Dhital, Bibek3, Author              
Knösche, Thomas R.2, Author              
Anwander, Alfred4, Author              
Stepan, Holger5, Author
Sorge, Ina1, Author
Hirsch, Wolfgang1, Author
Affiliations:
1Department of Pediatric Radiology, University Hospital Leipzig, Germany, ou_persistent22              
2Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5 Department of Obstetrics, University Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Fetus; Magnetic resonance imaging; Brain development; Postmortem; Gini coefficient; Proof-of-concept study; Multidimensional; Diffusion-weighted imaging (DWI)
 Abstract: Background Diffusion-weighted imaging (DWI) is important in the assessment of fetal brain development. However, it is clinically challenging and time-consuming to prepare neuromorphological examinations to assess real brain age and to detect abnormalities. Objective To demonstrate that the Gini coefficient can be a simple, intuitive parameter for modelling fetal brain development. Materials and methods Postmortem fetal specimens(n = 28) were evaluated by diffusion-weighted imaging (DWI) on a 3-T MRI scanner using 60 directions, 0.7-mm isotropic voxels and b-values of 0, 150, 1,600 s/mm2. Constrained spherical deconvolution (CSD) was used as the local diffusion model. Fractional anisotropy (FA), apparent diffusion coefficient (ADC) and complexity (CX) maps were generated. CX was defined as a novel diffusion metric. On the basis of those three parameters, the Gini coefficient was calculated. Results Study of fetal brain development in postmortem specimens was feasible using DWI. The Gini coefficient could be calculated for the combination of the three diffusion parameters. This multidimensional Gini coefficient correlated well with age (Adjusted R2 = 0.59) between the ages of 17 and 26 gestational weeks. Conclusions We propose a new method that uses an economics concept, the Gini coefficient, to describe the whole brain with one simple and intuitive measure, which can be used to assess the brain’s developmental state.

Details

show
hide
Language(s): eng - English
 Dates: 2014-02-202013-10-272014-04-092014-05-102014-10-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00247-014-3002-4
PMID: 24816372
Other: Epub 2014
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Pediatric Radiology
  Abbreviation : Pediatr Radiol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin, New York : Springer
Pages: - Volume / Issue: 44 (10) Sequence Number: - Start / End Page: 1290 - 1301 Identifier: ISSN: 0301-0449
CoNE: /journals/resource/0301-0449