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  Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

Agudo Torres, R., & Reetz, M. T. (2013). Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution. Chemical Communications, 49(93), 10914-10916. doi:10.1039/c3cc46229c.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-D5E6-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-D5EC-B
Genre: Journal Article

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 Creators:
Agudo Torres, Rubén1, Author           
Reetz, Manfred T.1, 2, Author           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
2Univ Marburg, Fachbereich Chemie, D-35032 Marburg, Germany, ou_persistent22              

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 Abstract: Designer cells for a synthetic cascade reaction harnessing selective redox reactions were devised, featuring two successive regioselective P450-catalyzed CH-activating oxidations of 1-cyclohexene carboxylic acid methyl ester followed by stereoselective olefin-reduction catalysed by (R)- or (S)-selective mutants of an enoate reductase.

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 Dates: 2013
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1039/c3cc46229c
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Pages: - Volume / Issue: 49 (93) Sequence Number: - Start / End Page: 10914 - 10916 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413