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  The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering

Reetz, M. T. (2013). The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker, 52(10), 2658-2666. doi:10.1002/anie.201207842.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-D5CA-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0018-D5CD-2
Genre: Journal Article

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 Creators:
Reetz, Manfred T.1, 2, Author           
Affiliations:
1Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
2Univ Marburg, D-35032 Marburg, Germany, ou_persistent22              

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Free keywords: directed evolution; enzymes; mutational additivity; mutational non-additivity; saturation mutagenesis
 Abstract: Additive or non-additive, that is the question: The increasing awareness of non-additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemistry and biotechnology profits from this intriguing development.

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 Dates: 2013-02-042013-03-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201207842
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Title: Angewandte Chemie International Edition : a journal of the Gesellschaft Deutscher Chemiker
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 52 (10) Sequence Number: - Start / End Page: 2658 - 2666 Identifier: ISSN: 0570-0833
CoNE: https://pure.mpg.de/cone/journals/resource/110984073528720