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  The swinging lever-arm hypothesis of muscle contraction

Holmes, K. C. (1997). The swinging lever-arm hypothesis of muscle contraction. Current Biology, 7(2), R112-R118. doi:10.1016/S0960-9822(06)00051-0.

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CurrBiol_7_1997_112.pdf (Any fulltext), 3MB
 
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Holmes, Kenneth C.1, 2, 3, Author           
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1Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society, ou_1497735              
2Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
3Muscle Research, Max Planck Institute for Medical Research, Max Planck Society, ou_1497731              

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 Abstract: The molecular mechanism of muscle contraction is a problem that has exercised biophysicists and biochemists for many years. The common view of the mechanism is embodied in the ‘cross-bridge hypothesis’, in which the relative sliding of thick (myosin) and thin (actin) filaments in cross-striated muscle is brought about by the ‘cross-bridges’, parts of the myosin molecules which protrude from the thick filaments and interact cyclically with the actin filaments, transporting them by a rowing action that is powered by the hydrolysis of ATP. This hypothesis is, however, rather vague on the molecular details of cross-bridge movement and, in the light of the recently determined crystal structures of myosin and actin, it has evolved into the more precise ‘swinging lever-arm hypothesis’.

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Language(s): eng - English
 Dates: 2004-04-101997-02-01
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666408
DOI: 10.1016/S0960-9822(06)00051-0
URI: http://www.ncbi.nlm.nih.gov/pubmed/9081660
Other: 4609
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Title: Current Biology
  Other : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 7 (2) Sequence Number: - Start / End Page: R112 - R118 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107