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  Control of kinetic properties of AMPA receptor channels by nuclear RNA editing

Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., et al. (1994). Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science, 266(5191), 1709-1713. doi:10.1126/science.7992055.

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Lomeli, Hilda, Author
Mosbacher, Johannes1, Author              
Melcher, Thorsten2, Author              
Höger, Thomas, Author
Geiger, Jörg R. P., Author
Kuner, Thomas1, 2, 3, 4, 5, Author              
Monyer, Hannah2, Author              
Higuchi, Miyoko2, Author              
Bach, Alfred W. J., Author
Seeburg, Peter H.2, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Interdisciplinary WIN-Research Group on Olfactory Dynamics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497717              
4Synaptic Transmission MNTB, Max Planck Institute for Medical Research, Max Planck Society, ou_1497745              
5Synaptic Transmission, Max Planck Institute for Medical Research, Max Planck Society, ou_1497744              

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 Abstract: AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear RNA editing controls the calcium permeability of these channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain. In three of the four AMPA receptor subunits (GluR-B, -C, and -D), intronic elements determine a codon switch (AGA, arginine, to GGA, glycine) in the primary transcripts in a position termed the R/G site, which immediately precedes the alternatively spliced modules "flip" and "flop." The extent of editing at this site progresses with brain development in a manner specific for subunit and splice form, and edited channels possess faster recovery rates from desensitization.

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Language(s): eng - English
 Dates: 1994-07-291994-09-281994-12-09
 Publication Status: Published in print
 Pages: 5
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666754
DOI: 10.1126/science.7992055
URI: https://www.ncbi.nlm.nih.gov/pubmed/7992055
Other: 4093
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 266 (5191) Sequence Number: - Start / End Page: 1709 - 1713 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1