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  A molecular determinant for submillisecond desensitization in glutamate receptors

Mosbacher, J., Schöpfer, R., Monyer, H., Burnashev, N., Seeburg, P. H., & Ruppersberg, J. P. (1994). A molecular determinant for submillisecond desensitization in glutamate receptors. Science, 266: 5187, pp. 1059-1061. doi:10.1126/science.7973663.

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Mosbacher, Johannes1, Author              
Schöpfer, Ralf2, Author              
Monyer, Hannah2, Author              
Burnashev, Nail1, Author              
Seeburg, Peter H.2, Author              
Ruppersberg, J. Peter1, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The decay of excitatory postsynaptic currents in central neurons mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is likely to be shaped either by receptor desensitization or by offset after removal of glutamate from the synaptic cleft. Native AMPA receptors show desensitization time constants of 1 to about 10 milliseconds, but the underlying molecular determinants of these large differences are unknown. Cloned AMPA receptors carrying the "flop" splice variants of glutamate receptor subtype C (GluR-C) and GluR-D are shown to have desensitization time constants of around 1 millisecond, whereas those with the "flip" variants are about four times slower. Cerebellar granule cells switch their expression of GluR-D splice variants from mostly flip forms in early stages to predominantly flop forms in the adult rat brain. These findings suggest that rapid desensitization of AMPA receptors can be regulated by the expression and alternative splicing of GluR-D gene transcripts.

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Language(s): eng - English
 Dates: 1994-07-281994-09-131994-11-11
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665161
DOI: 10.1126/science.7973663
URI: https://www.ncbi.nlm.nih.gov/pubmed/7973663
Other: 6926
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 266 Sequence Number: 5187 Start / End Page: 1059 - 1061 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1