English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  A molecular determinant for submillisecond desensitization in glutamate receptors

Mosbacher, J., Schöpfer, R., Monyer, H., Burnashev, N., Seeburg, P. H., & Ruppersberg, J. P. (1994). A molecular determinant for submillisecond desensitization in glutamate receptors. Science, 266: 5187, pp. 1059-1061. doi:10.1126/science.7973663.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-A8A5-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-AF99-C
Genre: Journal Article

Files

show Files
hide Files
:
Science_266_1994_1059.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
Science_266_1994_1059.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://science.sciencemag.org/content/266/5187/1059/tab-pdf (Any fulltext)
Description:
-
OA-Status:
Locator:
https://doi.org/10.1126/science.7973663 (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Mosbacher, Johannes1, Author           
Schöpfer, Ralf2, Author           
Monyer, Hannah2, Author           
Burnashev, Nail1, Author           
Seeburg, Peter H.2, Author           
Ruppersberg, J. Peter1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: The decay of excitatory postsynaptic currents in central neurons mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is likely to be shaped either by receptor desensitization or by offset after removal of glutamate from the synaptic cleft. Native AMPA receptors show desensitization time constants of 1 to about 10 milliseconds, but the underlying molecular determinants of these large differences are unknown. Cloned AMPA receptors carrying the "flop" splice variants of glutamate receptor subtype C (GluR-C) and GluR-D are shown to have desensitization time constants of around 1 millisecond, whereas those with the "flip" variants are about four times slower. Cerebellar granule cells switch their expression of GluR-D splice variants from mostly flip forms in early stages to predominantly flop forms in the adult rat brain. These findings suggest that rapid desensitization of AMPA receptors can be regulated by the expression and alternative splicing of GluR-D gene transcripts.

Details

show
hide
Language(s): eng - English
 Dates: 1994-07-281994-09-131994-11-11
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665161
DOI: 10.1126/science.7973663
URI: https://www.ncbi.nlm.nih.gov/pubmed/7973663
Other: 6926
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 266 Sequence Number: 5187 Start / End Page: 1059 - 1061 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1