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  Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression

Jonas, P., Racca, C., Sakmann, B., Seeburg, P. H., & Monyer, H. (1994). Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron, 12(6), 1281-1289. doi:10.1016/0896-6273(94)90444-8.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-A90C-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-B0D3-1
Genre: Journal Article

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 Creators:
Jonas, Peter1, Author              
Racca, Claudia, Author
Sakmann, Bert1, Author              
Seeburg, Peter H.2, Author              
Monyer, Hannah3, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2External Organizations, ou_persistent22              
3Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors critically depends on the subunit composition. Using patch-clamp techniques in brain slices, we found that the Ca2+ permeability of native AMPA-type GluRs was markedly higher in nonpyramidal (PCa/PK approximately 0.63) than in pyramidal (PCa/PK approximately 0.05) neurons of rat neocortex. Analysis of mRNA in single cells indicated that the relative abundance of GluR-B-specific mRNA was significantly lower in nonpyramidal (GluR-B/GluR-non-B approximately 0.3) than in pyramidal (GluR-B/GluR-non-B approximately 3) cells. This suggests that differences in relative abundance of GluR-B-specific mRNA generate functional diversity of AMPA-type GluRs in neurons with respect to Ca2+ permeability.

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Language(s): eng - English
 Dates: 1994-02-181994-03-302004-04-221994-06
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Method: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 12 (6) Sequence Number: - Start / End Page: 1281 - 1289 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565