English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Hypothesis: Intermediate filament and related proteins: Potential activators of nucleosomes during transcription initiation and elongation?

Traub, P., & Shoeman, R. L. (1994). Hypothesis: Intermediate filament and related proteins: Potential activators of nucleosomes during transcription initiation and elongation? Bioessays, 16(5), 349-355. doi:10.1002/bies.950160510.

Item is

Files

show Files
hide Files
:
BioEss_16_1994_349.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
BioEss_16_1994_349.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://doi.org/10.1002/bies.950160510 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Traub, Peter1, Author              
Shoeman, Robert L.2, 3, 4, Author              
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
2Coherent diffractive imaging, Max Planck Institute for Medical Research, Max Planck Society, ou_1497692              
3Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              
4Analytical Protein Biochemistry, Max Planck Institute for Medical Research, Max Planck Society, ou_1497690              

Content

show
hide
Free keywords: -
 Abstract: Intermediate filament (IF) protein tetramers contain two DNA- and core-histone-binding motifs in rotational symmetry in one and the same structural entity. We propose that IF protein oligomers might displace histone octamers from nucleosomes in the process of transcription initiation and elongation, to deposit them transiently on their α-helical coiled-coil domains. We further propose that structurally related proteins of the karyoskeleton, constructed from an α-helical domain capable of coiled-coil formation and a basic DNA-binding region adjacent to it, may be similarly involved in nucleosome activation. These proteins would function as auxiliary factors that disrupt nucleosomal structure to permit transcription and other DNA-dependent processes to proceed expiditiously.

Details

show
hide
Language(s): eng - English
 Dates: 1994-03-032005-02-051994-05
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665604
DOI: 10.1002/bies.950160510
Other: 6370
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Bioessays
  Other : Bioessays
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, UK : Co. of Biologists
Pages: - Volume / Issue: 16 (5) Sequence Number: - Start / End Page: 349 - 355 Identifier: ISSN: 0265-9247
CoNE: https://pure.mpg.de/cone/journals/resource/954925499109