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  Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11

Uetz, P., Abdelatty, F., Villarroel, A., Rappold, G. A., Weiss, B., & Koenen, M. (1994). Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11. FEBS Letters, 339(3), 302-306. doi:10.1016/0014-5793(94)80435-4.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-A939-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2443-F
Genre: Journal Article

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FEBSLett_339_1994_302.pdf (Any fulltext), 687KB
 
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 Creators:
Uetz, Peter1, Author              
Abdelatty, Fawzy, Author
Villarroel, Alfredo1, Author              
Rappold, Gudrun A., Author
Weiss, Birgit, Author
Koenen, Michael1, 2, 3, 4, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society, ou_1497727              
3Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
4Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society, ou_1497748              

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Free keywords: Serotonin; Gene structure; Alternative splicing; Mouse brain; Exon alignment
 Abstract: We have isolated the murine gene encoding the 5−HT3 receptor (5−HT3R), a member of the ligand−gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5−HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5−HT3R variants. The 5−HT3R gene, whose structure is closely related to neuronal and muscle AchRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11

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Language(s): eng - English
 Dates: 1993-12-221994-01-121994-02-21
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 339 (3) Sequence Number: - Start / End Page: 302 - 306 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501