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  Okadaic acid co-induces vimentin expression and cell cycle arrest in MPC-11 mouse plasmacytoma cells

Giese, G., Wiegers, W., Kubbies, M., Scherbarth, A., & Traub, P. (1995). Okadaic acid co-induces vimentin expression and cell cycle arrest in MPC-11 mouse plasmacytoma cells. Journal of Cellular Physiology, 163(1), 146-154. doi:10.1002/jcp.1041630117.

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Giese, Günter1, 2, Author              
Wiegers, W.3, Author              
Kubbies, Manfred, Author
Scherbarth, Annemarie1, 2, Author              
Traub, Peter3, Author              
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Light Microscopy Facility, Max Planck Institute for Medical Research, Max Planck Society, ou_1497720              
3Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: The effect of the tumor promoter okadaic acid on cell cycle progression and on vimentin expression in MPC-11 mouse plasmacytoma cells was compared with that of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Cell cycle progression of asynchronously grown MPC-11 cells was inhibited by both agents, but, in contrast to the G1 phase arrest caused by TPA, okadaic acid gave rise to G2/M phase and S phase arrest. This effect of okadaic acid was delayed significantly compared to the TPA-caused arrest. Furthermore, okadaic acid was able to induce vimentin expression to an extent comparable to the TPA response. However, vimentin expression was markedly delayed in okadaic acid-treated relative to TPA-treated cells. Another protein phosphatase inhibitor, calyculin A, also induced cell cycle changes and vimentin expression at concentrations at or above 1 x 10(-9) M. Based on these observations, we suggest an involvement of protein phosphatase 1 (possibly also phosphatase 2A and/or other phosphatases) in both the G2/M cell cycle block and the induction of vimentin expression in MPC-11 cells by okadaic acid.

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Language(s): eng - English
 Dates: 1993-01-271993-09-121995-04-01
 Publication Status: Published in print
 Pages: 10
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 Rev. Type: Peer
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Title: Journal of Cellular Physiology
  Other : J. Cell. Physiol.
Source Genre: Journal
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Publ. Info: Hoboken, NJ : Wiley Subscription Services, Inc.
Pages: - Volume / Issue: 163 (1) Sequence Number: - Start / End Page: 146 - 154 Identifier: ISSN: 0021-9541
CoNE: https://pure.mpg.de/cone/journals/resource/110992357271180