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  Studying block in cloned N-methyl--aspartate (NMDA) receptors

Ruppersberg, J. P., Mosbacher, J., Günther, W., Schöpfer, R., & Fakler, B. (1993). Studying block in cloned N-methyl--aspartate (NMDA) receptors. Biochemical Pharmacology, 46(11), 1877-1885. doi:10.1016/0006-2952(93)90627-9.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-A9EB-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-24A3-A
Genre: Journal Article
Alternative Title : Commentary Studying block in cloned N-methyl--aspartate (NMDA) receptors

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BiochemPharmacol_46_1993_1877.pdf (Any fulltext), 735KB
 
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 Creators:
Ruppersberg, J. Peter1, Author              
Mosbacher, Johannes1, Author              
Günther, Willy1, Author              
Schöpfer, Ralf2, Author              
Fakler, Bernd3, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: The biophysics of block of NMDA receptor channels has been investigated extensively during the past 8 years. In the last few years, cloned NMDA receptor channels have become available. Here we have discussed advantages and disadvantages of studying block phenomena in cloned NMDA receptors. Some recent work on the pore block of the cloned NMDA receptor channels was critically reviewed and extended by data about the calcium block. Novel effects of kainate on cloned NMDA receptors and of NMDA on cloned AMPA receptors were reported and discussed with respect to recent work concerning possible occurrence of NMDA-AMPA hybrid channels.

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Language(s): eng - English
 Dates: 1993-12-03
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Biochemical Pharmacology
Source Genre: Journal
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Publ. Info: Amsterdam, Boston : Elsevier
Pages: - Volume / Issue: 46 (11) Sequence Number: - Start / End Page: 1877 - 1885 Identifier: ISSN: 0006-2952
CoNE: https://pure.mpg.de/cone/journals/resource/954925384102