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  Differential laminar expression of AMPA receptor genes in the developing rat visual cortex using in situ hybridization histochemistry. Effect of visual deprivation

Rößner, S., Kumar, A. S., Kues, W., Witzemann, V., & Schliebs, R. (1993). Differential laminar expression of AMPA receptor genes in the developing rat visual cortex using in situ hybridization histochemistry. Effect of visual deprivation. Int. J. Dev. Neurosci., 11(4), 411-424. doi:10.1016/0736-5748(93)90015-6.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-AA25-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-2646-C
Genre: Journal Article

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IntJDevlNeuroscience_11_1993_411.pdf (Any fulltext), 2MB
 
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Rößner, Steffen, Author
Kumar, Ashok Sampath, Author
Kues, Winfried1, Author           
Witzemann, Veit1, 2, 3, 4, Author           
Schliebs, Reinhard, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society, ou_1497748              
4Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society, ou_1497727              

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 Abstract: The postnatal development of laminar pattern of AMPA receptor mRNA subtypes GluR-A through to GluR-D (flip variants) in the visual cortex of both normally raised and monocularly deprived rats (one eyelid sutured at the age of 11 days) was studied using in situ hybridization histochemistry and computer-assisted image analysis. The AMPA receptors GluR-A through to GluR-D transcripts exhibit a differential laminar expression pattern in the developing rat visual cortex. At birth the levels of GluR-A transcripts are lower by about 50% in each visual cortical layer as compared to the adult values. In contrast, GluR-B to GluR-D mRNAs are expressed in all cases at higher levels at birth than in the adult brain. Unilateral eyelid closure at postnatal day 11 for several periods of time resulted in both transient and permanent changes in the laminar development of GluR-A through to GluR-C transcripts but hardly affected the GluR-D mRNA subtype. The distinct laminar developmental pattern of AMPA receptor mRNAs in rat visual cortex as well as the differential effects of visual deprivation suggest specific roles of AMPA receptor subtypes during the early postnatal maturation of visual function.

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Language(s): eng - English
 Dates: 1993-05-141993-05-191993-08-01
 Publication Status: Issued
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666797
DOI: 10.1016/0736-5748(93)90015-6
URI: https://www.ncbi.nlm.nih.gov/pubmed/8237460
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Title: Int. J. Dev. Neurosci.
  Other : Int. J. Dev. Neurosci.
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 11 (4) Sequence Number: - Start / End Page: 411 - 424 Identifier: ISSN: 0736-5748
CoNE: https://pure.mpg.de/cone/journals/resource/954925536103_1