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  Structure of the actin-myosin complex and its implications for muscle contraction

Rayment, I., Holden, H. M., Whittaker, M., Yohn, C. B., Lorenz, M., Holmes, K. C., et al. (1993). Structure of the actin-myosin complex and its implications for muscle contraction. Science, 261(5117), 58-65. doi:10.1126/science.8316858.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-AA36-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-26BF-B
Genre: Journal Article

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 Creators:
Rayment, Ivan, Author
Holden, Hazel M., Author
Whittaker, Michael, Author
Yohn, Christopher B., Author
Lorenz, Michael1, 2, Author           
Holmes, Kenneth C.1, 3, 4, Author           
Milligan, Ronald A., Author
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
3Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society, ou_1497735              
4Muscle Research, Max Planck Institute for Medical Research, Max Planck Society, ou_1497731              

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 Abstract: Muscle contraction consists of a cyclical interaction between myosin and actin driven by the concomitant hydrolysis of adenosine triphosphate (ATP). A model for the rigor complex of F actin and the myosin head was obtained by combining the molecular structures of the individual proteins with the low-resolution electron density maps of the complex derived by cryo-electron microscopy and image analysis. The spatial relation between the ATP binding pocket on myosin and the major contact area on actin suggests a working hypothesis for the crossbridge cycle that is consistent with previous independent structural and biochemical studies.

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Language(s): eng - English
 Dates: 1993-04-061993-06-011993-07-02
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665086
DOI: 10.1126/science.8316858
URI: https://www.ncbi.nlm.nih.gov/pubmed/8316858
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 261 (5117) Sequence Number: - Start / End Page: 58 - 65 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1