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  Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes

Kuner, T., Schöpfer, R., & Korpi, E. R. (1993). Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. NeuroReport, 5(3), 297-300. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/7905294.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-AAC2-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-1AFB-6
Genre: Journal Article
Alternative Title : Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes

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NeuroRep_5_1994_297.pdf (Any fulltext), 287KB
 
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Kuner, Thomas1, 2, Author              
Schöpfer, Ralf1, Author              
Korpi, Esa R., Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C subunit combinations. Concentration-dependent inhibition was observed at ethanol concentrations of > or = 50 mM both in Ca(2+)-containing and Ca(2+)-deficient, Ba(2+)-containing Mg(2+)-free media. The NR1-NR2C channels were slightly less sensitive to ethanol inhibition than the other heteromeric channels in Ca(2+)-deficient, Ba(2+)-containing medium. The inhibition was unaffected by the clamping-voltage and by a mutation [NR1-NR2A(N595Q)] that prevents the Mg(2+)-blockade of the channels, indicating that the mechanism of action of ethanol differs from that of Mg2+. The results are consistent with the hypothesis that the NMDA receptor subtypes can mediate many behavioural actions of ethanol.

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Language(s): eng - English
 Dates: 1993-09-131993-09-261993-12-13
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666814
URI: https://www.ncbi.nlm.nih.gov/pubmed/7905294
Other: 4010
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Title: NeuroReport
Source Genre: Journal
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Publ. Info: Oxford, UK : Rapid Communications of Oxford Ltd.
Pages: - Volume / Issue: 5 (3) Sequence Number: - Start / End Page: 297 - 300 Identifier: ISSN: 0959-4965
CoNE: https://pure.mpg.de/cone/journals/resource/954925578070