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  Two independently regulated secretory pathways in mast cells

Kirillova, J., Thomas, P., & Almers, W. (1993). Two independently regulated secretory pathways in mast cells. Journal of Physiology (Paris), 87(3), 203-208. doi:10.1016/0928-4257(93)90031-N.

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Genre: Journal Article
Alternative Title : Two independently regulated secretory pathways in mast cells

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 Creators:
Kirillova, J., Author
Thomas, Paul, Author
Almers, Wolfhard1, Author           
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1Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society, ou_1497703              

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Free keywords: secretory pathways; Ca2+; hormone secretion; eosinophils
 Abstract: We review here evidence that mast cells independently secrete large and small vesicles. Release of small vesicles is triggered by Ca2+. Combining capacitance measurements and flash photolysis of caged Ca2+, we demonstrate Ca-triggered exocytosis that is kinetically identical to the release of dense-core peptidergic vesicles from pituitary melanotrophs. It is suggested that the secretory pathway used for hormone secretion in neuroendocrine cells is also active in mast cells and eosinophils. The nature of the mediator thus secreted is unknown.

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Language(s): eng - English
 Dates: 1993
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665074
DOI: 10.1016/0928-4257(93)90031-N
Other: 7011
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Title: Journal of Physiology (Paris)
Source Genre: Journal
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Publ. Info: Paris : Elsevier
Pages: - Volume / Issue: 87 (3) Sequence Number: - Start / End Page: 203 - 208 Identifier: ISSN: 0928-4257
CoNE: https://pure.mpg.de/cone/journals/resource/954926945756_1