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  Heteromeric NMDA receptors: molecular and functional distinction of subtypes

Monyer, H., Sprengel, R., Schöpfer, R., Herb, A., Higuchi, M., Lomeli, H., et al. (1992). Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science, 256(5060), 1217-1221. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1350383.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-AB69-E Version Permalink: http://hdl.handle.net/21.11116/0000-0002-60D1-5
Genre: Journal Article

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 Creators:
Monyer, Hannah1, Author              
Sprengel, Rolf1, Author              
Schöpfer, Ralf1, Author              
Herb, Anne1, Author              
Higuchi, Miyoko1, Author              
Lomeli, Hilda, Author
Burnashev, Nail2, Author              
Sakmann, Bert2, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage-dependent sensitivity to magnesium and is modulated by glycine. Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence. These are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor subunits, including the NMDA receptor subunit NMDAR1 (NR1). Upon expression in cultured cells, the new subunits yielded prominent, typical glutamate- and NMDA-activated currents only when they were in heteromeric configurations with NR1. NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Such heteromeric NMDA receptor subtypes may exist in neurons, since NR1 messenger RNA is synthesized throughout the mature rat brain, while NR2 messenger RNA show a differential distribution.

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Language(s): eng - English
 Dates: 1992-03-301992-04-281992-05-22
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: URI: http://www.ncbi.nlm.nih.gov/pubmed/1350383
URI: 10.1126/science.256.5060.1217
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Title: Science
  Other : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 256 (5060) Sequence Number: - Start / End Page: 1217 - 1221 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1