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  2H-benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles

Iddon, B., Kutschy, P., Robinson, A. G., Suschitzky, H., Kramer, W., & Neugebauer, F. A. (1992). 2H-benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles. Journal of the Chemical Society, Perkin Transactions 1, 22: 2/03252J, pp. 3129-3134. doi:10.1039/P19920003129.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-ABB6-F Version Permalink: https://hdl.handle.net/21.11116/0000-0002-5500-E
Genre: Journal Article

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JChemSocPerkinTrans_1_1992_3129.pdf (Any fulltext), 850KB
 
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http://pubs.rsc.org/en/content/articlepdf/1992/p1/p19920003129 (Any fulltext)
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https://doi.org/10.1039/P19920003129 (Any fulltext)
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 Creators:
Iddon, Brian, Author
Kutschy, Peter, Author
Robinson, Andrew G., Author
Suschitzky, Hans, Author
Kramer, Walter, Author
Neugebauer, Franz A.1, Author           
Affiliations:
1Department of Organic Chemistry, Max Planck Institute for Medical Research, Max Planck Society, ou_1497706              

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 Abstract: A new synthesis of the selective anthelmintic agent triclabendazole 7 from the readily available 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 2 by simple steps is described. Analogous benzi-midazoles difficult to prepare by conventional methods are similarly obtained. Triclabendazole can exist as a low-melting metastable solid (m.p. 85–90 °C) convertible by heating or recrystallisation from ethanol into its stable form (m.p. 176–178 °C).

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Language(s): eng - English
 Dates: 1992-06-221992-08-051992
 Publication Status: Issued
 Pages: 6
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/P19920003129
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Title: Journal of the Chemical Society, Perkin Transactions 1
Source Genre: Journal
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Publ. Info: London : Royal Society of Chemistry
Pages: - Volume / Issue: 22 Sequence Number: 2/03252J Start / End Page: 3129 - 3134 Identifier: ISSN: 1472-7781
CoNE: https://pure.mpg.de/cone/journals/resource/111053443082010_1