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  The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits

Herb, A., Burnashev, N., Werner, P., Sakmann, B., Wisden, W., & Seeburg, P. H. (1992). The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron, 8, 775-785. doi:10.1016/0896-6273(92)90098-X.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-AC34-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-60B6-4
Genre: Journal Article

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Neuron_8_1992_775.pdf (Any fulltext), 11MB
 
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 Creators:
Herb, Anne1, Author              
Burnashev, Nail2, Author              
Werner, Pia1, Author              
Sakmann, Bert2, Author              
Wisden, William, Author
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: A new ionotropic glutamate receptor subunit termed KA-2, cloned from rat brain cDNA, exhibits high affinity for [3H]kainate (KD approximately 15 nM). KA-2 mRNA is widely expressed in embryonic and adult brain. Homomeric KA-2 expression does not generate agonist-sensitive channels, but currents are observed when KA-2 is coexpressed with GluR5 or GluR6 subunits. Specifically, coexpression of GluR5(R) and KA-2 produces channel activity, whereas homomeric expression of either subunit does not. Currents through heteromeric GluR5(Q)/KA-2 channels show more rapid desensitization and different current-voltage relations when compared with GluR5(Q) currents. GluR6/KA-2 channels are gated by AMPA, which fails to gate homomeric GluR6 receptor channels. These results suggest possible in vivo partnership relations for high affinity kainate receptors.

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Language(s): eng - English
 Dates: 1992-01-211991-12-092004-09-071992-04-01
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 8 Sequence Number: - Start / End Page: 775 - 785 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565