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  Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation

Ruppersberg, J. P., Stocker, M., Pongs, O., Heinemann, S. H., Frank, R., & Koenen, M. (1991). Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature, 352(6337), 711-714. doi:10.1038/352711a0.

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Ruppersberg, J. Peter1, Author              
Stocker, Martin, Author
Pongs, Olaf, Author
Heinemann, Stefan H., Author
Frank, R., Author
Koenen, Michael1, 2, 3, 4, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society, ou_1497727              
3Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
4Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society, ou_1497748              

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 Abstract: Modulation of neuronal excitability by regulation of K+ channels potentially plays a part in short-term memory but has not yet been studied at the molecular level. Regulation of K+ channels by protein phosphorylation and oxygen has been described for various tissues and cell types; regulation of fast-inactivating K+ channels mediating IK(A) currents has not yet been described. Functional expression of cloned mammalian K+ channels has provided a tool for studying their regulation at the molecular level. We report here that fast-inactivating K+ currents mediated by cloned K+ channel subunits derived from mammalian brain expressed in Xenopus oocytes are regulated by the reducing agent glutathione. This type of regulation may have a role in vivo to link metabolism to excitability and to regulate excitability in specific membrane areas of mammalian neurons.

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Language(s): eng - English
 Dates: 1991-04-291991-07-031991-08-22
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 352 (6337) Sequence Number: - Start / End Page: 711 - 714 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238