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  A family of AMPA-selective glutamate receptors

Keinänen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T. A., et al. (1990). A family of AMPA-selective glutamate receptors. Science, 249(4968), 556-560. doi:10.1126/science.2166337.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-AD0C-E Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7D43-9
Genre: Journal Article

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Science_249_1990_556.pdf (Any fulltext), 4MB
 
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 Creators:
Keinänen, Kari, Author
Wisden, William, Author
Sommer, Bernd, Author
Werner, Pia1, Author              
Herb, Anne1, Author              
Verdoorn, Todd A., Author
Sakmann, Bert2, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).

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Language(s): eng - English
 Dates: 1990-06-201990-07-161990-08-03
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 249 (4968) Sequence Number: - Start / End Page: 556 - 560 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1