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  Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS

Sommer, B., Keinänen, K., Verdoorn, T. A., Wisden, W., Burnashev, N., Herb, A., et al. (1990). Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science, 249(4976), 1580-1585. doi:10.1126/science.1699275.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-AD31-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-7F88-9
Genre: Journal Article

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 Creators:
Sommer, Bernd, Author
Keinänen, Kari, Author
Verdoorn, Todd A., Author
Wisden, William, Author
Burnashev, Nail1, Author              
Herb, Anne2, Author              
Köhler, Martin2, Author              
Takagi, T., Author
Sakmann, Bert1, Author              
Seeburg, Peter H.2, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: In the central nervous system (CNS), the principal mediators of fast synaptic excitatory neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). In each member of a family of four abundant AMPA receptors, a small segment preceding the predicted fourth transmembrane region has been shown to exist in two versions with different amino acid sequences. These modules, designated "flip" and "flop," are encoded by adjacent exons of the receptor genes and impart different pharmacological and kinetic properties on currents evoked by L-glutamate or AMPA, but not those evoked by kainate. For each receptor, the alternatively spliced messenger RNAs show distinct expression patterns in rat brain, particularly in the CA1 and CA3 fields of the hippocampus. These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.

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Language(s): eng - English
 Dates: 1990-08-061990-09-051990-09-28
 Publication Status: Published in print
 Pages: 6
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 Table of Contents: -
 Rev. Method: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 249 (4976) Sequence Number: - Start / End Page: 1580 - 1585 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1