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  Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain

Stühmer, W., Ruppersberg, J. P., Schröter, K., Sakmann, B., Stocker, M., Giese, K. P., et al. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO Journal, 8(11), 3235-3244. doi:10.1002/j.1460-2075.1989.tb08483.x.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-ADF5-F Version Permalink: https://hdl.handle.net/21.11116/0000-0000-8EC4-3
Genre: Journal Article

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http://onlinelibrary.wiley.com/doi/10.1002/j.1460-2075.1989.tb08483.x/epdf (Any fulltext)
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 Creators:
Stühmer, Walter, Author
Ruppersberg, J. Peter1, Author           
Schröter, Klaus1, Author           
Sakmann, Bert1, Author           
Stocker, Martin, Author
Giese, K. P., Author
Perschke, A., Author
Baumann, Ariane, Author
Pongs, Olaf, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: channel diversity; gene family; mammalian brain; potassium channels
 Abstract: Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.

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Language(s): eng - English
 Dates: 1989-06-201989-07-311989-11
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/j.1460-2075.1989.tb08483.x
URI: https://www.ncbi.nlm.nih.gov/pubmed/2555158
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC401447/
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Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 8 (11) Sequence Number: - Start / End Page: 3235 - 3244 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061