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  Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21

Schlichting, I., Wittinghofer, A., & Rösch, P. (1988). Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21. Biochemical and Biophysical Research Communications, 150(1), 444-448. doi:10.1016/0006-291X(88)90540-2.

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BiochemBiophysResComm_150_1988_444.pdf (Any fulltext), 236KB
 
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Schlichting, Ilme1, 2, Author           
Wittinghofer, Alfred2, Author           
Rösch, Paul2, Author           
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1Photoreceptors, Max Planck Institute for Medical Research, Max Planck Society, ou_1856341              
2Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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 Abstract: Two-dimensional proton NMR studies were performed on the c-Ha-ras encoded proto-oncogene product p21C. COSY and NOESY spectra of the p21C.GDP.Mg2+ complex show that the ribose H1 proton of the bound GDP is in close proximity to the aromatic side chain of a phenylalanyl residue. From sequence homology with the bacterial elongation factor Tu (EF-Tu) and the known X-ray structure of the EF-Tu.GDP.Mg2+ complex it may be inferred that the Phe residue in question is either Phe78 or Phe82 in the p21 sequence.

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Language(s): eng - English
 Dates: 1987-11-172004-12-081988-01-15
 Publication Status: Published in print
 Pages: 5
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 Table of Contents: -
 Rev. Type: Peer
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Title: Biochemical and Biophysical Research Communications
  Other : Biochem. Biophys. Res. Commun.
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 150 (1) Sequence Number: - Start / End Page: 444 - 448 Identifier: ISSN: 0006-291X
CoNE: https://pure.mpg.de/cone/journals/resource/954922652205_1